Diet and lead toxicity

Diet and lead toxicity.

Introduction There is no known biological function for lead and any lead absorbed by man or by animal may be classified as potentially toxic. These toxic effects are many, ranging from morphological damage to tissues at higher concentrations, to lesser biochemical effects at lower concentrations. In biochemical systems lead will generally inhibit enzyme activity and result in clinical effects s...

Lead toxicity.

BACKGROUND Since the last In-Depth Review of lead toxicity in 2004 there have been further developments with regard to safe exposure levels for lead workers. AIMS To advise occupational health professionals of the latest research on the multi-system toxic effects of lead and the implications of this research for setting new safe and appropriate occupational suspension limits. METHODS An ext...

Lead toxicity and heme biosynthesis.

Lead intoxication results in a disturbance of heme biosynthesis, its degree depending on the severity and duration of exposure to lead. A mild secondary, sideroblastic anemia is common; basophilic stippling may occur, especially in severe lead poisoning. Increased excretion in the urine of delta-aminolevulinic acid and coproporphyrin III may occur; porphobilinogen excretion is not usually incre...

Lead toxicity and nutritional deficiencies.

Under appropriate conditions, deficiencies of certain minerals and vitamins as well as high intakes of dietary fat increase the toxicity of a given dose of lead in experimental animals. The severity of lead poisoning can also be increased by the consumption of either deficient or excessive levels of protein. Mineral deficiencies appear to have some of the most profound effects on lead toxicity,...

Iron Nutrition and Lead Toxicity